It’s time for bioavailability at home

Increasing fluid overload can reduce the intestinal absorption of diuretics, compromising bioavailability.1-3 Through subcutaneous administration, FUROSCIX is able to deliver at-home, IV-equivalent diuresis with 99.6% absolute bioavailability—even in the presence of fluid overload.1

In an open-label, crossover study

FUROSCIX AND IV FUROSEMIDE DEMONSTRATED EQUIVALENT BIOAVAILABILITY and diuresis1*

FUROSCIX AND IV FUROSEMIDE DEMONSTRATED EQUIVALENT BIOAVAILABILITY and diuresis1*

FUROSCIX Achieved 99.6% Absolute Bioavailability1

a graph depicting the bioavailability of furoscix over time

FUROSCIX demonstrated Diuretic Equivalence to IV Furosemide1†

a graph comparing furoscix diuresis compared to IV furosemide diuresis

FUROSCIX reached Therapeutic plasma furosemide levels within 30 minutes

Urine output was seen within 60 minutes1,2

Urine sodium excretion for FUROSCIX1

286 mmol

0-8 H

341 mmol

0-24 H

Open-label, crossover study design1:

  • Study subjects represented likely FUROSCIX patients
    • NYHA Class II and Class III chronic heart failure
    • Fluid overload treated with oral diuretics for at least 3 months
  • Patients discontinued oral furosemide at least 24 hours prior to study treatment
  • Patients randomized to either drug, then received alternate treatment after 7-day wash out
Furosemide can cause dehydration and azotemia. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, furosemide should be discontinued.

*

90% confidence interval of 94.8-104.8. The design of the device used in this study was different from the current FUROSCIX On-Body Infusor, but it used the same administration profile.

Urine output over the periods of 0 to 8 hours and 0 to 24 hours following administration of 80-mg furosemide by 5-hour subcutaneous infusion with FUROSCIX, or IV administration of 2 doses of 40 mg 2 hours apart. Time 0 indicates the start of diuresis therapy.

Based on mean +/- SD 30-minute plasma concentration of 600 (± 209) ng/mL.1

SD=standard deviation.